Pathway analysis – Communicable Diseases Research

Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approach

Short communication

Published on 2022-12-012022-10-05
Journal: Biochemistry and Biophysics Reports
[Category] 신약개발,

Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review

Article

Published on 2022-11-012022-11-16
Journal: Annals of Clinical and Translational Neurology
[Category] 변종,

Interplay between demographic, clinical and polygenic risk factors for severe COVID-19

Article

Published on 2022-10-132022-11-15
Journal: International Journal of Epidemiology
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] 95% CI adjusted odds ratio Admission age antiviral response association co-morbidity conducted COVID-19 COVID-19 diagnosis Critical care death develop diagnosed with COVID-19 enrolment Epidemiology European Factor Factors General population genetic data genetic risk factor Genetic variant greater highest hospital Hospitalization identify IMPROVE individual interquartile range lowest median men morbidity obesity outcomes participant Pathway analysis Pathways Patient polygenic risk score polymorphism PRS reported risk risk factor risk prediction. severe COVID-19 single-nucleotide Smokers socio-demographic UK biobank was performed
[DOI] 10.1093/ije/dyac137 PMC 바로가기

Multi-Omics Reveals Mechanisms of Partial Modulation of COVID-19 Dysregulation by Glucocorticoid Treatment

Article

Published on 2022-10-112022-11-16
Journal: International Journal of Molecular Sciences
[Category] 유전자 메커니즘,

Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning method

Research article

Published on 2022-10-012022-10-05
Journal: Applied Soft Computing
[Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술,

Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma

Article

Published on 2022-09-232022-11-15
Journal: Frontiers in Immunology
[Category] 바이오마커, 유전자 메커니즘,

[키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription
[DOI] 10.3389/fimmu.2022.988479 PMC 바로가기

Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune system

Article

Published on 2022-09-122022-11-15
Journal: PLoS ONE
[Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

Network Pharmacology and Bioinformatics Analysis Identifies Potential Therapeutic Targets of Paxlovid Against LUAD/COVID-19

Article

Published on 2022-09-082022-11-16
Journal: Frontiers in Endocrinology
[Category] SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome Against Analysis approved bioinformatics bioinformatics. caused Clinical characteristics Clinical data contagious coronavirus Coronavirus disease 2019 correlation country COVID-19 COX Cytoscape downloaded drug drug target DrugBank evaluate evaluated Fatality rate FDA Features food functional Gene Expression GeneCards Genes GO enrichment analysis IL-17 IL12B IL6 include infected with COVID-19 Interaction KEGG LBP lung adenocarcinoma (LUAD) lung cancer patient management mechanism modulate molecular molecular docking Mortality NCBI network network pharmacology pandemic pathway Pathway analysis Patient Paxlovid Pharmacology Potential potential therapeutic target Prognosis prognostic receptor Regression model risk SARS-CoV-2 screened signaling pathway survival rate susceptibility SwissTargetPrediction target target gene TargetNet therapeutic target Transcriptome Treatment Venn diagram virus was performed was used while
[DOI] 10.3389/fendo.2022.935906 PMC 바로가기

Network analysis for elucidating the mechanisms of Shenfu injection in preventing and treating COVID-19 combined with heart failure

Research article

Published on 2022-09-012022-10-05
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘,

[키워드] acting acute respiratory syndrome Analysis approach biological process biological processe caused cell differentiation China Chinese components Compound compound screening coronavirus COVID-19 COVID-19 case Critical cytokine signaling Cytoscape Cytoscape software Diagnosis drug-likeness Effectiveness enrichment analysis Evidence heart failure Hemostasis identify IL-17 immune system indicated Infection Inflammatory response injection involved KEGG pathway Kyoto Lung injury mechanism Medicine National Health Commission network network analysis novel coronavirus disease objective overlapped Pathway analysis Pathway enrichment analysis Pathways patients with COVID-19 pharmacological mechanism Pharmacological mechanisms Pharmacology progression protein-protein interaction regulated Respiratory failure Result SARS-CoV-2 Shenfu injection signaling pathway Stage suggested syndrome System target targets TCM Th17 therapeutic therapy Traditional treat treating COVID-19 Treatment was used
[DOI] 10.1016/j.compbiomed.2022.105845 [Article Type] Research article

Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Research article

Published on 2022-08-242022-10-05
Journal: The Lancet. Respiratory Medicine
[Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] admitted to ICU Affect affecting Analysis Antwerp Aspergillus autophagy Belgium Bronchoalveolar lavage fluid bronchoalveolar lavage sample bronchoalveolar lavage samples calculate Cell chemokines collected Concentration conidia COVID-19 Critically ill patient Cytokines development diagnose differentially expressed disrupting downregulated downregulation elevated Eligible patients encoding protein enrichment analysis epithelial European expression expression data finding foundation fraction France function funding Gene expression analysis growth factor Horizon hospital hyphae ICU IFNγ IL-1β Immunity in vivo increased mortality Influenza Influenza virus Innate immunity intensive care invasive invasive ventilation investigated kill killing lung epithelial Max Planck Society network neutrophil Neutrophils Non-invasive pathophysiology pathway Pathway analysis Pathways Patient patients patients with COVID-19 patients with influenza performed phagocytosis Protein recruited Regional retrieved SARS-COV-2 infection SARS-CoV-2 RNA several gene significantly significantly lower spores TNF-α tracheobronchial transcriptomics Treatment Type I IFN type II IFN university University Hospitals Leuven were used
[DOI] 10.1016/S2213-2600(22)00259-4 [Article Type] Research article